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KMID : 1037020200090020095
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Medical Lasers; Engineering, Basic Research, and Clinical Application
2020 Volume.9 No. 2 p.95 ~ p.102
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Phototherapy in Allergic Rhinitis: From In Vitro Studies to Clinical Trials
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Yoo Shin-Hyuk
Chung Young-Jun
Bae Jun-Sang
Mo Ji-Hun
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Abstract
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Phototherapy has a profound immunosuppressive effect and is widely used for the treatment of inflammatory skin diseases. Since allergic rhinitis (AR) shares several common pathologic features with atopic dermatitis, intranasal phototherapy is a novel approach for treating AR. Phototherapy reduces the antigen presenting capacity of dendritic cells, induces apoptosis of immune cells, and inhibits synthesis and release of pro-inflammatory mediators from inflammatory cells. The effectiveness of phototherapy for AR has been extensively researched: from in vitro studies to several clinical trials. Data indicates the potential of intranasal phototherapy as an alternative treatment for AR as well as other inflammatory mucosal diseases. In this review, we introduce the in vitro, in vivo studies, and clinical trials which demonstrated the effect of phototherapy on AR.
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KEYWORD
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Phototherapy, Allergic rhinitis, Laser, Low-level laser therapies
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